Medication Monday: Doxycycline
It’s Medication Monday! 💊 Today I’m talking about doxycycline, a tetracycline antibiotic.
Is it safe when lactating? 👍🏻 (short-term)
Is it safe when pregnant? 👎🏻
Is it safe for baby? 👍🏻
Is is safe for SUPPLY? 👍🏻
Doxycycline is a tetracycline antibiotic. It is used to treat a variety of infections and conditions, such as acne, anthrax, lyme disease, periodontitis, sexually transmitted infections, and the plague.
Doxycycline inhibits protein synthesis and alters the cytoplasmic membrane in susceptible bacteria. Ultimately, doxycycline weakens the bacteria, allowing the immune system to clear the infection.
Doxycycline is available in immediate and delayed release formulations. It comes in tablet, capsule, liquid, and intravenous forms. The immediate release formulation peaks 1.5-4 hours of administration, and the delayed release formulation peaks 3 hours of administration. The half-life for both formulations is 18-22 hours.
Doxycycline should not be used during pregnancy unless the benefits exceed the risks. The tetracycline class of antibiotics crosses the placenta and has been shown to accumulate in the growing teeth and bones of the fetus. Teeth can be permanently stained yellow, gray, or brown, and bone growth can be delayed following long-xterm or repeat exposure. Doxycycline has the least staining of the tetracyclines. However, sometimes the use of doxycycline in pregnancy is warranted. It is the drug of choice for Rocky Mountain spotted fever in pregnant women. The benefits of doxycycline must be weighed against the risks of doxycycline and treatment must be individualized.
Doxycycline can be used safely in lactation. It has a relative infant dose of 4.2% to 13.3%. Research regarding doxycycline during lactation is minimal, but what research is available demonstrates minimal to no side effects in the breastfed infant. Short-term use (3 weeks or less) is considered acceptable in lactation.
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